5,6-Dihydro-5-Fluorouracil, CAS [[696-06-0]]

Product Overview

• Article Name: 5,6-Dihydro-5-Fluorouracil, CAS [[696-06-0]]
• Biozol Catalog Number: MCE-HY-134160
• Supplier Catalog Number: HY-134160
• Alternative Catalog Number: MCE-HY-134160-10MG,MCE-HY-134160-5MG,MCE-HY-134160-1MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: 5-DHFU, 5-Fluorodihydropyrimidine-2,4-dione, 5-Fluorodihydrouracil

Product Description

5,6-Dihydro-5-Fluorouracil (5-DHFU, 5-Fluorodihydropyrimidine-2,4-dione) is the active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (HY-90006), which is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-Dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50=13.5 µM). Intravenous administration of 5,6-Dihydro-5-Fluorouracil (90 mg/kg/wk) in combination with 5-fluorouracil and the DPD inhibitor eniluracil (HY-10533) slows tumor growth in a rat colon cancer model.

Product Properties

• Molecular Weight: 132.09
• Purity: 99.90
• CAS Number: [696-06-0]
• Formula: C4H5FN2O2
• Target: Nucleoside Antimetabolite/Analog

Application Notes

• Application Notes: MCE Product type: Reference compound