KW-2478 (hydrochloride), CAS [[819812-18-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-13468A
Supplier Catalog Number:
HY-13468A
Alternative Catalog Number:
MCE-HY-13468A-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
KW-2478 hydrochloride is an HSP90 inhibitor (IC50 = 3.8 nM). KW-2478 hydrochloride inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 hydrochloride weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 hydrochloride downregulates STAT3 expression. KW-2478 hydrochloride may be used in research on cancers such as CML and liver cancer[1][2].
Molecular Weight:
611.12
CAS Number:
[819812-18-5]
Formula:
C30H43ClN2O9
Target:
Apoptosis,Bcr-Abl,CDK,HSP,p38 MAPK,STAT
Application Notes:
MCE Product type: Reference compound
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