SBI-0087702 promots the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCepsilon[1].
Molecular Weight:
321.41
Purity:
99.55
CAS Number:
[864431-36-7]
Formula:
C21H23NO2
Target:
PKC
Application Notes:
MCE Product type: Reference compound
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