N-alpha-Tosyl-Lys chloromethyl ketone (hydrochloride), CAS [[4238-41-9]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-137038
Supplier Catalog Number:
HY-137038
Alternative Catalog Number:
MCE-HY-137038-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
TLCK (hydrochloride)
N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is an irreversible inhibitor for serine protease, which inhibits trypsin and trypsin-like protease by alkylating histidine residues in their active site. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride inhibits caspase-3, caspase-6 and caspase-7, with IC50s of 12.0, 54.5 and 19.3 µM, respectively. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride induces apoptosis in cell HL-60, and inhibits the decrease in mitochondrial transmembrane potential during apoptosis[1].
Molecular Weight:
369.31
CAS Number:
[4238-41-9]
Formula:
C14H22Cl2N2O3S
Target:
Caspase,Ser/Thr Protease
Application Notes:
MCE Product type: Reference compound
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