PROTAC BRAF-V600E degrader-1, CAS [[2417296-84-3]]

Product Overview

• Article Name: PROTAC BRAF-V600E degrader-1, CAS [[2417296-84-3]]
• Biozol Catalog Number: MCE-HY-137487
• Supplier Catalog Number: HY-137487
• Alternative Catalog Number: MCE-HY-137487-5MG,MCE-HY-137487-1MG,MCE-HY-137487-10MG,MCE-HY-137487-25MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

PROTAC BRAF-V600E degrader-1 (compound 23) is a potent PROTAC BRAF-V600E degrader whlie no degradation activity against BRAF-WT. PROTAC BRAF-V600E degrader-1 exhibits Kd values of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS) and inhibits the growth of melanoma cells[1]. (In the molecular structure, target protein ligand: BI-882370 (HY-107779), red part, E3 ubiquitin enzyme ligand: Pomalidomide (HY-10984), blue part, PROTAC linker: G007-LK (HY-12438), black part.

Product Properties

• Molecular Weight: 1001.07
• Purity: 98.04
• CAS Number: [2417296-84-3]
• Formula: C48H54F2N10O10S
• Target: PROTACs,Raf

Application Notes

• Application Notes: MCE Product type: Reference compound