Bexotegrast (PLN-74809) is an orally active, potent dual alphavbeta6/alphavbeta1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits alphavbeta6- and alphavbeta1-induced TGF-beta activation with IC50 values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-beta activation in the fibrotic lung[1][2].
Molecular Weight:
492.61
Purity:
99.74
CAS Number:
[2376257-44-0]
Formula:
C27H36N6O3
Target:
Integrin
Application Notes:
MCE Product type: Reference compound
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