RK-582 is an orally active, spiroindoline-based selective inhibitor of tankyrase. The IC50s of RK-582 against TNKS1/PARP5A and PARP1 are 36.1 nM and 18.168 nM, respectively. RK-582 inhibits rectal cancer COLO-320DM cells (GI50=0.23 µM) and significantly inhibits tumor growth in a COLO-320DM mouse xenograft model[1].
Molecular Weight:
510.60
Purity:
98.05
CAS Number:
[2171388-28-4]
Formula:
C27H35FN6O3
Target:
PARP
Application Notes:
MCE Product type: Reference compound
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