RK-582 is a tankyrase inhibitor, antitumor agent, and orally bioavailable growth inhibitor, with an IC50 of 36.1 nM against human tankyrase-1 and an IC50 of 39.2 nM against human tankyrase-2. In APC-mutated colorectal cancer cells, the sensitivity to RK-582 correlates with the level of active beta-catenin, while drug resistance associates with PIK3CA mutation. RK-582 can be used for the research of colorectal cancer[1][2].
Molecular Weight:
510.60
Purity:
98.05
CAS Number:
[2171388-28-4]
Formula:
C27H35FN6O3
Target:
PARP
Application Notes:
MCE Product type: Reference compound
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