BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162)[1].
Molecular Weight:
837.38
Purity:
99.87
CAS Number:
[2519823-34-6]
Formula:
C40H49ClN8O8S
Target:
CDK,PROTACs
Application Notes:
MCE Product type: Reference compound
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