3-Oxobetulin acetate (28-O-Acetyl-3-Oxobetulin, 3-oxo-28-O-Acetylbetulin) is a derivative of betulin (HY-N0083), a cholesterol biosynthesis inhibitor. 3-Oxobetulin acetate inhibits the growth of P388 murine lymphocytic leukemia cells (EC50=0.12 µg/mL) and human MCF-7 breast cancer, SF-268 CNS cancer, H460 lung cancer, and KM20L2 colon cancer cells (GI50s=8, 10.6, 5.2, and 12.7 µg/mL), but not BxPC-3 pancreatic cancer cells or DU145 prostate cancer cells (GI50s=>10 µg/mL for both). 3-Oxobetulin acetate inhibits the replication of X4-tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50=13.4 µM). 3-Oxobetulin acetate is also effective against Listeria donovani amastigotes.
Molecular Weight:
482.74
CAS Number:
[136587-07-0]
Formula:
C32H50O3
Target:
Bacterial,Drug Derivative,HIV
Application Notes:
MCE Product type: Reference compound
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