Simufilam (PTI-125) is an orally active FLNA modulator. Simufilam restores NMDAR signaling and Arc expression. Simufilam inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Abeta42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam can be used for research of Alzheimers disease[1][2][3].
Molecular Weight:
259.35
Purity:
98.08
CAS Number:
[1224591-33-6]
Formula:
C15H21N3O
Target:
Amyloid-beta,iGluR,mTOR,Tau Protein
Application Notes:
MCE Product type: Reference compound
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