DDC-01-163, CAS [[2140806-84-2]]

Product Overview

• Article Name: DDC-01-163, CAS [[2140806-84-2]]
• Biozol Catalog Number: MCE-HY-139997
• Supplier Catalog Number: HY-139997
• Alternative Catalog Number: MCE-HY-139997-100MG,MCE-HY-139997-50MG,MCE-HY-139997-25MG,MCE-HY-139997-10MG,MCE-HY-139997-5MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

DDC-01-163 is an allosteric PROTAC degrader targeting EGFR. DDC-01-163 is dependent on the ubiquitin-proteasome system. DDC-01-163 can selectively inhibit the proliferation of L858R/T790M (L/T) mutant Ba/F3 cells. DDC-01-163 is effective against Osimertinib (HY-15772)-resistant cells with L/T/C797S and L/T/L718Q EGFR mutations. DDC-01-163 exhibits enhanced anti-proliferative activity against L858R/T790M EGFR-Ba/F3 cells when combined with the ATP-site EGFR inhibitor Osimertinib. DDC-01-163 can be used for the study of non-small cell lung cancer[1].

Product Properties

• Molecular Weight: 942.05
• Purity: 99.05
• CAS Number: [2140806-84-2]
• Formula: C49H51N9O9S
• Target: EGFR,PROTACs

Application Notes

• Application Notes: MCE Product type: Reference compound