GNF2133 is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3beta, respectively. GNF2133 shows good proliferation potency and efficacy on rat and human primary beta-cell. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 has the potential for the research of type 1 diabetes[1].
Molecular Weight:
434.53
Purity:
99.67
CAS Number:
[2561414-56-8]
Formula:
C24H30N6O2
Target:
DYRK
Application Notes:
MCE Product type: Reference compound
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