Necrocide 1, a necrosis by sodium overload (NECSO) inducer, is a selective transient receptor potential melastatin 4 (TRPM4) agonist with an EC50 of 306.3 nM for human TRPM4. Necrocide 1 triggers TRPM4-dependent necrotic cell death through the induction of sodium influx. Necrocide 1 induces hallmarks of immunogenic cell death incurring calreticulin (CALR) exposure, ATP secretion and high mobility group box 1 (HMGB1) release. Necrocide 1 can be used for the study of breast and prostate cancer[1][2][3].
Molecular Weight:
365.47
Purity:
99.55
CAS Number:
[1247028-61-0]
Formula:
C23H27NO3
Target:
Eukaryotic Initiation Factor (eIF),Reactive Oxygen Species (ROS),TRP Channel
Application Notes:
MCE Product type: Reference compound
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