Encaleret (CLTX-305) sodium is an orally active antagonist of the calcium-sensing receptor (CaSR), with an IC50 of 12 nM. Encaleret sodium exerts its effect by inhibiting the excessive activity of functional gain-of-function CaSR variants, and can restore blood calcium levels, promote the secretion of parathyroid hormone, improve magnesium and phosphorus metabolism, and increase urinary calcium excretion. Encaleret sodium can be used in the research of diseases such as osteoporosis and autosomal dominant hypocalcemia type 1[1][2].
Molecular Weight:
536.01
CAS Number:
[787584-62-7]
Formula:
C29H32ClFNNaO4
Target:
CaSR,Thyroid Hormone Receptor
Application Notes:
MCE Product type: Reference compound
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