PP-C8 is a potent and selective PROTAC CDK12-Cyclin K degrader. PP-C8 induces CDK12-Cyclin K degradation with DC50s of 416 and 412 nM for CDK12 and Cyclin K, respectively. PP-C8 demonstrates profound synergistic antiproliferative effects with PARP inhibitor in triple-negative breast cancer (TNBC)[1].
Molecular Weight:
866.94
Purity:
99.99
CAS Number:
[3032108-74-7]
Formula:
C43H51FN12O7
Target:
CDK,PROTACs
Application Notes:
MCE Product type: Reference compound1
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