KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. In addition, KL-11743 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis[1][2][3][4].
Molecular Weight:
522.60
Purity:
99.40
CAS Number:
[1369452-53-8]
Formula:
C30H30N6O3
Target:
Disulfidptosis,GLUT
Application Notes:
Reference compound
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