FGFR4-IN-8, CAS [[2765240-52-4]] Preis auf Anfrage

Product Overview

• Article Name: FGFR4-IN-8, CAS [[2765240-52-4]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-145836
• Supplier Catalog Number: HY-145836
• Alternative Catalog Number: MCE-HY-145836-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

FGFR4-IN-8 (Compound 7v) is an ATP-competitive, highly selective covalent inhibitor of wild-type and gatekeeper mutant FGFR4. FGFR4-IN-8 exhibits excellent potency against FGFR4, FGFR4V550L, FGFR4V550M and FGFR4C552S with IC50s of 0.5, 0.25, 1.6, 931 nM, respectively. FGFR4-IN-8 exhibits potent antiproliferative activity against Hep3B hepatocellular carcinoma cells with the IC50 value of 29 nM. FGFR4-IN-8 demonstrates modest in vivo antitumor efficacy in nude mice bearing the Huh-7 xenograft model[1].

Product Properties

• Molecular Weight: 654.56
• CAS Number: [2765240-52-4]
• Formula: C32H34Cl2FN7O3
• Target: FGFR

Application Notes

• Application Notes: MCE Product type: Reference compound