PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-beta1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3',5'-cyclic adenosine monophosphate) and cGMP (3',5'-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research[1].
Molecular Weight:
535.63
CAS Number:
[3031349-98-8]
Formula:
C33H33N3O4
Target:
Calcium Channel,Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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