Setidegrasib (KRAS G12D inhibitor 17, ASP3082) is a PROTAC KRAS degrader (DC50: 37 nM). Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib suppresses p-ERK, p-AKT, p-S6 levels in AsPC-1 cells. Setidegrasib exhibits anti-tumor activity in various cancer xenograft models in mice. Setidegrasib can be used for the study of KRAS(G12D)-mutated solid tumors. (Blue: VHL ligase ligand (HY-168699), Black: linker (HY-168698), Pink: G12D ligand (HY-168700))[1][2].
Molecular Weight:
1117.30
Purity:
99.65
CAS Number:
[2821793-99-9]
Formula:
C60H65FN12O7S
Target:
Akt,ERK,PROTACs,Ras
Application Notes:
MCE Product type: Reference compound
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