KTX-951 is an orally active IRAK4 and IMiD (Ikaros/Aiolos) substrates PROTAC degrader (Kd = 3.5 nM). KTX-951 has DC50s of 13 nM, 14 nM and 13 nM for IRAK4, Ikaros and Aiolos, respectively. KTX-951 has IC50 of 35 nM for OCl-Ly10 CTG. KTX-951 has antitumor activity.(Pink: IRAK4 ligand-12 (HY-48932), Black: Linker (HY-W382009), Blue: CRBN Ligand Pomalidomide (HY-10984))[1].
Molecular Weight:
850.95
Purity:
99.60
CAS Number:
[2573298-36-7]
Formula:
C46H52F2N8O6
Target:
IRAK,PROTACs
Application Notes:
MCE Product type: Reference compound
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