NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr2 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL), and regulates CDK4 expression[1].
Molecular Weight:
926.44
Purity:
98.99
Formula:
C46H30ClIrN6O2
Target:
CDK,Mixed Lineage Kinase,RIP kinase
Application Notes:
MCE Product type: Reference compound
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