eIF4A3-IN-18 (compound 74) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis[1].
Molecular Weight:
500.54
Purity:
99.58
CAS Number:
[1402931-84-3]
Formula:
C29H28N2O6
Target:
Eukaryotic Initiation Factor (eIF)
Application Notes:
MCE Product type: Reference compound
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