Relutrigine (PRAX-562) is an orally active inhibitor of persistent sodium channel. Relutrigine potently and preferentially inhibits persistent INa induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC50 values of 141 nM and 75 nM, respectively. Relutrigine exhibits potent use-dependent block and reduces neuronal intrinsic excitability. Relutrigine has effective anticonvulsant activity[1].
Molecular Weight:
407.27
Purity:
99.13
CAS Number:
[2392951-29-8]
Formula:
C15H11F6N5O2
Target:
Sodium Channel
Application Notes:
MCE Product type: Reference compound1
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