Risvodetinib (IkT-148009) is an orally active, selective and brain-penetrant protein tyrosine kinase inhibitor, displaying excellent target efficacy against c-Abl1, c-Abl2/Arg with IC50 values of 33 nM, 14 nM, respectively. Risvodetinib suppresses c-Abl activation and substantially protects dopaminergic neurons from degeneration in mouse models of both inherited and sporadic Parkinsons disease (PD), which is promising for research in the field of PD[1][2][3][4].
Molecular Weight:
574.68
Purity:
99.21
CAS Number:
[2031185-00-7]
Formula:
C33H34N8O2
Target:
Bcr-Abl,c-Met/HGFR
Application Notes:
MCE Product type: Reference compound
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