E722-2648 is an inhibitor targeting the BCL9 and beta-catenin complex with antitumor activity. E722-2648 blocks complex formation by disrupting the interaction between the two proteins, thereby inhibiting beta-catenin-mediated transcriptional activity and downregulating the expression of WNT target genes. E722-2648 effectively inhibits tumor growth in colon cancer xenograft models and colorectal cancer mouse models. E722-2648 can be used for the research of colon cancer and colorectal cancer[1][2].
Molecular Weight:
390.61
CAS Number:
[931963-55-2]
Formula:
C21H30N2OS2
Target:
Bcl-2 Family,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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