GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 µM and inhibits SMARCA2 with an EC50 of 0.10 µM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 µM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis[1].
Molecular Weight:
327.38
Purity:
99.65
CAS Number:
[1997321-20-6]
Formula:
C17H21N5O2
Target:
Epigenetic Reader Domain
Application Notes:
MCE Product type: Reference compound
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