Bardoxolone, CAS [[218600-44-3]]

Product Overview

• Article Name: Bardoxolone, CAS [[218600-44-3]]
• Biozol Catalog Number: MCE-HY-14909
• Supplier Catalog Number: HY-14909
• Alternative Catalog Number: MCE-HY-14909-5MG,MCE-HY-14909-10MG,MCE-HY-14909-100MG,MCE-HY-14909-50MG,MCE-HY-14909-10MMX1ML
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: CDDO, RTA 401

Product Description

Bardoxolone (RTA 401, CDDO) is an orally active activator of nuclear regulatory factor (NRf-2) and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC50 value of 0.43 µM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC50 value of 1.30 µM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury[1][2].

Product Properties

• Molecular Weight: 491.66
• Purity: 99.50
• CAS Number: [218600-44-3]
• Formula: C31H41NO4
• Target: Keap1-Nrf2,Necroptosis,SARS-CoV,Virus Protease

Application Notes

• Application Notes: Reference compound