PROTAC ERalpha Degrader-4 (Compound ZD12) is a highly potent and selectivePROTAC ERalpha degrader (Ki: 5.08 µM). PROTAC ERalpha Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERalpha Degrader-4 shows excellent cell inhibitory and ERalpha degradation activity against Tamoxifen-sensitive and -resistant ER+ breast cancer (BC) cells and ERalpha-mutated BC cells. PROTAC ERalpha Degrader-4 can induce apoptosis and can be used for cancer research.
Molecular Weight:
1074.23
Purity:
99.06
CAS Number:
[2521299-80-7]
Formula:
C55H62F3N5O10S2
Target:
Apoptosis,Estrogen Receptor/ERR,PROTACs
Application Notes:
MCE Product type: Reference compound
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