RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion[1].
Molecular Weight:
305.36
Purity:
95.98
CAS Number:
[3052303-53-1]
Formula:
C16H11N5S
Target:
Mixed Lineage Kinase,RIP kinase
Application Notes:
MCE Product type: Reference compound
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