ARD-2051 is a selective and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. ARD-2051 achieves DC50 values of 0.6 nM for AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines. ARD-2051 exhibits effective anti-tumor activity in VCaP xenograft mice model. ARD-2051 can be used for the research of prostate cancer (Pink: AR ligand (HY-400666), Blue: CRBN Ligand (HY-14658), Black: Linker)[1].
Molecular Weight:
789.32
Purity:
98.57
CAS Number:
[2632305-17-8]
Formula:
C43H45ClN8O5
Target:
Androgen Receptor,PROTACs
Application Notes:
MCE Product type: Reference compound
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