KRas G12R inhibitor 1 is a covalent inhibitor targeting the common oncogenic mutant KRas G12R with selectivity for the mutant arginine. KRas G12R inhibitor 1 possesses an alpha,beta-diketoamide and exploits strong nucleophilicity of the mutant cysteine and irreversibly binds in the Switch II region of KRas. KRas G12R inhibitor 1 can be researched for K-Ras (G12R)-driven cancer such as pancreatic ductal adenocarcinoma (PDAC)[1].
Molecular Weight:
903.20
Purity:
98.19
Formula:
C39H38ClF7N6O9
Target:
Ras
Application Notes:
MCE Product type: Reference compound
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