Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41.9 nM. Nampt degrader-2 binds to NAMPT and VHL to form a ternary complex and subsequently induced NAMPT degradation via ubiquitin-proteasome system (UPS). Nampt degrader-2 leads to significant reduction of NAD+ and exerts potent antitumor activities[1].
Molecular Weight:
1052.33
Purity:
99.41
CAS Number:
[3035008-40-0]
Formula:
C59H73N9O7S
Target:
NAMPT,PROTACs
Application Notes:
MCE Product type: Reference compound
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