Zomiradomide is an orally active PROTAC degrader for IRAK4 (DC50=6 nM), thereby inhibiting the NF-kappaB signaling pathway. Zomiradomide acts also as a molecular glue, recruiting Ikaros and Aiolos, and mediating their degradation (DC50 for Ikaros is 1 nM), thereby activating the type I IFN signaling pathway[1][2][3]. (Pink: target protein ligand PROTAC IRAK4 ligand-5 (HY-168311), Blue: E3 ligase ligand Thalidomide-4-Br (HY-W039116), Black: linker (HY-168313))
Molecular Weight:
871.97
Purity:
95.43
CAS Number:
[2655656-99-6]
Formula:
C45H48F3N7O6S
Target:
IFNAR,IRAK,NF-kappaB,PROTACs
Application Notes:
Reference compound
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