Olezarsen (sodium), CAS [[2298451-31-5]]

Product Overview

• Article Name: Olezarsen (sodium), CAS [[2298451-31-5]]
• Biozol Catalog Number: MCE-HY-153491A
• Supplier Catalog Number: HY-153491A
• Alternative Catalog Number: MCE-HY-153491A-1MG,MCE-HY-153491A-5MG,MCE-HY-153491A-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: ISIS 678354 (sodium), IONIS-APOCIII-LRx (sodium), AKCEA-APOCIII-LRx (sodium)

Product Description

Olezarsen (ISIS 678354,IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease[1][2][3].

Product Properties

• Molecular Weight: 8684.86 (free acid)
• Purity: 96.53
• CAS Number: [2298451-31-5]
• Formula: C296H419N71Na20O154P20S19
• Target: Apolipoprotein

Application Notes

• Application Notes: MCE Product type: Oligonucleotides