BML-190(IMMA) is a potent and selective CB2 receptor ligand (Ki values are 435 nM and > 2 µM for CB2 and CB1 respectively). IC50 Value: 435 nM(Ki CB2) Target:CB2 receptor in vitro: BML-190 increases the accumulation of cAMP, via forskolin-stimulated mechanism in HEK-293 cells. Alternate studies suggest that BML-190 reduces the toxicity of culture supernatants to SH-SY5Y human neutroblastoma cells. Various research suggests that BML-190 is an essential tool in studying the proliferation of neuroblastoma. BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction. in vivo:
Molecular Weight:
426.89
Purity:
99.53
CAS Number:
[2854-32-2]
Formula:
C23H23ClN2O4
Target:
Cannabinoid Receptor
Application Notes:
MCE Product type: Reference compound
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