22-(4'-py)-JA, CAS [[1178895-15-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-155721
Supplier Catalog Number:
HY-155721
Alternative Catalog Number:
MCE-HY-155721-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
22-(4'-Pyridinecarbonyl) jorunnamycin A
22-(4'-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4'-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4'-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF). 22-(4'-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC)[1].
Molecular Weight:
598.60
CAS Number:
[1178895-15-2]
Formula:
C32H30N4O8
Target:
Akt,mTOR
Application Notes:
MCE Product type: Natural Products
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