DHFR-IN-9 (compound 8A) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-9 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=0.25 µg/mL) and has anti-infective effects in mouse models of systemic infection and thigh infection caused by it (dose: 2.5 mg /kg, 5 mg/kg, ip). DHFR-IN-9 has stronger anticancer activity than paclitaxel (Y-B0015) in a mouse model of breast cancer (dose: 2.5 mg/kg, ip, once every 3 days)[1].
Molecular Weight:
360.44
CAS Number:
[3032441-13-4]
Formula:
C19H16N6S
Target:
Bacterial,Dihydrofolate reductase (DHFR)
Application Notes:
MCE Product type: Reference compound
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