GSK-J4 (Standard) is the analytical standard of GSK-J4. This product is intended for research and analytical applications. GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 µM, respectively. GSK-J4 inhibits LPS-induced TNF-alpha production in human primary macrophages with an IC50 of 9 µM. GSK J4 is a cell permeable proagent of GSK-J1[1][2][3]. GSK-J4 induces endoplasmic reticulum stress-related apoptosis[4].
Molecular Weight:
417.50
CAS Number:
[1373423-53-0]
Formula:
C24H27N5O2
Target:
Apoptosis,Histone Demethylase,Reference Standards
Application Notes:
MCE Product type: Reference Standards
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