HJM-561 is a selective and effective orally active EGFR PROTAC degrader. HJM-561 is able to overcome the triple EGFR mutations that are resistant to Osimertinib (HY-15772). HJM-561 exhibits potent degradation of EGFR Del19/T790M/C797S (DC50: 9.2 nM) and L858R/T790M/C797S (DC50: 5.8 nM), and has anti-tumor activity (pink: EGFR ligand (HY-12857), blue: CRBN ligand (HY-A0003), black: linker)[1].
Molecular Weight:
864.37
Purity:
99.26
CAS Number:
[2570251-68-0]
Formula:
C45H51ClN9O5P
Target:
EGFR,PROTACs
Application Notes:
MCE Product type: Reference compound
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