AP736 is a potent tyrosinase inhibitor (IC50 = 0.9 µM) with anti-melanogenesis activity in normal human melanocytes (IC50 = 0.11 µM). AP736 suppresses the expression of tyrosinase and TRP-1/2 by inhibiting the cAMP-PKA-CREB signalling axis, leading to reduced microphthalmia-associated transcription factor (MITF) transcripts and proteins. AP736 can be used for melanogenesis and hyperpigmentation research[1][2].
Molecular Weight:
437.53
CAS Number:
[1365531-21-0]
Formula:
C26H31NO5
Target:
PKA,Tyrosinase
Application Notes:
MCE Product type: Reference compound
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