RIPK1-IN-17 is an orally active, selective RIPK1 inhibitor (Kd = 17 nM) and shows no significant inhibition to RIPK3. RIPK1-IN-17 specifically inhibits necroptosis rather than apoptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation. RIPK1-IN-17 protects mice from hypothermia and death. RIPK1-IN-17 can be used for the study of necroptosis-related diseases such as inflammatory response syndrome (SIRS)[1].
Molecular Weight:
529.51
Purity:
98.38
CAS Number:
[3033385-59-7]
Formula:
C26H19F4N3O3S
Target:
Mixed Lineage Kinase,Necroptosis,RIP kinase
Application Notes:
MCE Product type: Reference compound
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