FR173657 is an orally active bradykinin B2 receptor antagonist (IC50: 0.56, 1.5, 2.9 nM for pig, rat, human B2 receptor respectively). FR173657 (p.o.) inhibits BK-induced bronchoconstriction in guinea-pigs (ED50: 0.075 mg/kg). FR173657 (p.o.) also inhibits Carrageenin-induced paw oedema in mice (ED50: 6.8 mg/kg). FR173657 can be used for research of inflammatory disease[1].
Molecular Weight:
592.47
CAS Number:
[167838-64-4]
Formula:
C30H27Cl2N5O4
Target:
Bradykinin Receptor
Application Notes:
MCE Product type: Reference compound
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