CZC-25146, CAS [[1191911-26-8]]

Product Overview

• Article Name: CZC-25146, CAS [[1191911-26-8]]
• Biozol Catalog Number: MCE-HY-15800A
• Supplier Catalog Number: HY-15800A
• Alternative Catalog Number: MCE-HY-15800A-25MG,MCE-HY-15800A-100MG,MCE-HY-15800A-5MG,MCE-HY-15800A-10MMX1ML,MCE-HY-15800A-10MG,MCE-HY-15800A-50MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

CZC-25146 is a potent and orally active LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 can increase normal alpha-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 can be used to research Parkinsons disease and liver diseases[1][2][3].

Product Properties

• Molecular Weight: 488.54
• Purity: 99.10
• CAS Number: [1191911-26-8]
• Formula: C22H25FN6O4S
• Target: LRRK2,TNK1

Application Notes

• Application Notes: MCE Product type: Reference compound