BMS-986365, CAS [[2446928-30-7]]

Product Overview

• Article Name: BMS-986365, CAS [[2446928-30-7]]
• Biozol Catalog Number: MCE-HY-158101
• Supplier Catalog Number: HY-158101
• Alternative Catalog Number: MCE-HY-158101-100MG,MCE-HY-158101-25MG,MCE-HY-158101-1G,MCE-HY-158101-5MG,MCE-HY-158101-500MG,MCE-HY-158101-250MG,MCE-HY-158101-50MG,MCE-HY-158101-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: CC-94676

Product Description

BMS-986365 (CC-94676) is an orally active and selective targeted androgen receptor (AR) PROTAC degrader (DC50 of 10-40 nM). BMS-986365 is capable of inducing cereblon (CRBN) E3 ligase-dependent ubiquitination and degradation of the androgen receptor (AR), as well as various AR mutants. BMS-986365 shows no degradation of the close AR family members estrogen receptor (ER), progesterone receptor (PR), and glucocorticoid receptor (GR). BMS-986365 shows significant in vivo potency, degrading AR, inhibiting AR signaling, and restricting tumor growth in animal models of advanced prostate cancer. BMS-986365 can be used for the study of metastatic castration-resistant prostate cancer (mCRPC)[1][2][3][4].

Product Properties

• Molecular Weight: 818.91
• Purity: 99.92
• CAS Number: [2446928-30-7]
• Formula: C41H45F3N8O5S
• Target: Androgen Receptor,PROTACs

Application Notes

• Application Notes: MCE Product type: Reference compound