VVD-214, CAS [[3026500-20-6]]

Product Overview

• Article Name: VVD-214, CAS [[3026500-20-6]]
• Biozol Catalog Number: MCE-HY-158116
• Supplier Catalog Number: HY-158116
• Alternative Catalog Number: MCE-HY-158116-10MMX1ML,MCE-HY-158116-25MG,MCE-HY-158116-5MG,MCE-HY-158116-100MG,MCE-HY-158116-50MG,MCE-HY-158116-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: RO7589831, VVD-133214

Product Description

VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers[1][2].

Product Properties

• Molecular Weight: 437.46
• Purity: 99.99
• CAS Number: [3026500-20-6]
• Formula: C20H21F2N3O4S
• Target: DNA/RNA Synthesis

Application Notes

• Application Notes: MCE Product type: Reference compound