PROTAC TEAD degrader-1 is a TEAD2 degrader and antiproliferative agent with selective activity toward TEAD2 relative to other TEAD family members. PROTAC TEAD degrader-1 relies on CRBN and the proteasome system for TEAD2 degradation, disruption of CRBN binding attenuates this activity. PROTAC TEAD degrader-1 decreases expression of YAP target genes CYR61 and CTGF. PROTAC TEAD degrader-1 can be used for the research of NF2-deficient cancer[1].
Molecular Weight:
822.83
Purity:
99.82
CAS Number:
[3061498-57-2]
Formula:
C44H41F3N6O7
Target:
PROTACs,YAP
Application Notes:
MCE Product type: Reference compound
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