PROTAC TEAD degrader-1 (Compound 27) is a PROTAC degrader for transcriptional enhanced associate domain (TEAD). PROTAC TEAD degrader-1 selectively degrades the Flag TEAD2 in a ubiquitin proteasome-dependent manner, with a DC50 of 54.1 nM in 293T cells, inhibits proliferation of NF2-deficient NCI-H226 with an IC50 of 0.21 µM, and regulates expressions of yes associated protein (YAP) target genes. (Pink: TEAD ligand (HY-158400), Black: linker (HY-W008474), Blue: E3 ligase ligand (HY-W087383))[1]
Molecular Weight:
822.83
Purity:
99.82
CAS Number:
[3061498-57-2]
Formula:
C44H41F3N6O7
Target:
PROTACs,YAP
Application Notes:
MCE Product type: Reference compound
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