RP-2119 is an orally bioactive Polymerase Theta (Poltheta) inhibitor, with an IC50 of 0.7 nM against human Poltheta ATPase. RP-2119 reduces Poltheta activity and exerts antiproliferative effects in BRCA2-deficient cancer cells. RP-2119 exhibits antitumor activity in BRCA2-deficient cancer cell xenograft mouse models. RP-2119 can be used for the research of cancer and homologous recombination-deficient cancers, including brca1/brca2-mutant cancers and shld2-mutant cancers[1][2].
Molecular Weight:
507.52
Purity:
99.94
CAS Number:
[2922287-81-6]
Formula:
C24H19F2N7O2S
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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