2-APQC, CAS [[500271-63-6]]

Product Overview

• Article Name: 2-APQC, CAS [[500271-63-6]]
• Biozol Catalog Number: MCE-HY-158426
• Supplier Catalog Number: HY-158426
• Alternative Catalog Number: MCE-HY-158426-1G,MCE-HY-158426-100MG,MCE-HY-158426-250MG,MCE-HY-158426-10MG,MCE-HY-158426-10MMX1ML,MCE-HY-158426-500MG,MCE-HY-158426-25MG,MCE-HY-158426-50MG,MCE-HY-158426-5MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 µM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-beta/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure[1].

Product Properties

• Molecular Weight: 405.47
• Purity: 99.70
• CAS Number: [500271-63-6]
• Formula: C23H24FN5O
• Target: Sirtuin

Application Notes

• Application Notes: MCE Product type: Reference compound