GT-653 is a PROTAC degrader for lysine-specific demethylase 5B (KDM5B). GT-653 degrades 68.35% KDM5B at 10 µM in a ubiquitin proteasome-dependent manner, upregulates H3K4me3 levels, and activates the type-I interferon signaling pathway in prostate cancer cells 22RV1. (Pink: KDM5B ligand (HY-158433), Black: Linker (HY-W004896), Blue: E3 ligase ligand (HY-103596))[1]
Molecular Weight:
653.60
Purity:
99.84
Formula:
C32H27N7O9
Target:
Histone Demethylase,PROTACs
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
