SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1, AC) inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models[1][2].
Molecular Weight:
377.99
Purity:
99.70
CAS Number:
[2248703-42-4]
Formula:
C20H40ClNO3
Target:
Apoptosis,Bcl-2 Family,Ceramidase,LPL Receptor
Application Notes:
MCE Product type: Reference compound
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